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laughing
through
the tears
Written by LaurelLaurel Palladino
Hope in the Hardest Places: Alzheimer’s Breakthroughs, Hope and Laughter
Alzheimer's can be uncertain, but the future is faith-filled and forward-focused. Let's hold on to the hope that a breakthrough is around the corner.

It starts with a misplaced name. A forgotten date. A moment of confusion that seems harmless — until it’s not. Alzheimer’s disease has long been one of the most emotionally devastating diagnoses a family can face. It doesn’t just rob a person of memory; it slowly erases pieces of their identity, their stories, and their connection to loved ones. For caregivers and families, it’s a long goodbye marked by waves of grief, exhaustion, and resilience. But in the midst of this heartbreak, there is hope — real, tangible, scientific hope. And that hope is growing stronger by the year.

Breakthroughs That Matter

Recent years have brought encouraging developments in Alzheimer’s research, bringing us closer than ever to understanding, slowing, and potentially even preventing this devastating disease:

  1. Lecanemab (Leqembi): A New Chapter in Treatment

In 2023, the FDA fully approved Leqembi, the first Alzheimer’s drug to significantly slow cognitive decline in patients with early-stage disease. It targets beta-amyloid plaques in the brain — the hallmark of Alzheimer’s — and marks a significant step forward. While not a cure, it offers families precious time: more shared conversations, more remembered faces, more laughter through the tears.

  1. Blood Tests for Early Detection

Innovations in blood-based biomarkers are making it easier to detect Alzheimer’s before symptoms begin. This could allow interventions to start earlier, when treatments like Leqembi are most effective. Imagine a future where early detection becomes routine — catching Alzheimer’s before it takes hold.

  1. Gene Therapy and Lifestyle Interventions

Researchers are exploring gene therapy and precision medicine to target individuals most at risk. At the same time, studies reinforce the importance of lifestyle interventions: regular exercise, cognitive engagement, heart-healthy diets, and social connection — all of which can reduce risk or slow progression.

These breakthroughs matter because behind every clinical trial is a family. A spouse. A daughter. A son. People like me, who found ways to laugh even as they cried. Who discovered that joy and pain can coexist. Who learned that even when memory fades, love remains. I’m not trying to sugarcoat the exhaustion or the loss. But I also refuse to let them have the final word. Instead, I chose to walk through Alzheimer’s with grace, faith, and humor intact. Whether it’s a silly moment in the middle of a serious day, or a memory that resurfaces like a forgotten song, I try to remember to find light in the darkest corners. The little moments matter. Love can stretch across forgetting. We are not powerless in the face of this disease.

The journey through Alzheimer’s is never easy. But it is no longer without hope. As science advances, and people share their stories and memories, we are reminded that healing isn’t just in a lab — it’s in every caregiver’s perseverance, every shared laugh, every whispered prayer.

To those still walking this road: You are not alone. The tears are real — but so is the laughter. And if you need it, here is your reminder, sometimes laughter is what carries us through.

author avatar
Laurel Palladino

So, here’s my story…

I am Laurel, an author and advocate for those impacted by Alzheimer’s disease. Through my book, “Laughing Through The Tears,” I hope to shed light on the journey of those affected by this condition and offer a unique perspective that combines laughter and resilience.

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